Association between zinc and chronic hepatitis: A 2-sample Mendelian randomization study.

ABSTRACT: Micronutrients play a critical role in the development and progression of chronic hepatitis (CH). Variations in the levels of these essential nutrients can significantly influence disease outcomes in CH patients. This study investigates the causal relationships between 14 key micronutrients - copper, zinc, magnesium, vitamins A, C, D, B6, B12, folate, carotene, iron, selenium, calcium, and potassium - and the pathogenesis of CH. We utilized Mendelian randomization (MR) to explore causal relationships between 14 micronutrients and CH. Instrumental variables for micronutrient levels were derived from large-scale genome-wide association studies in European populations, with CH outcome data sourced from the FinnGen database. Our MR analysis employed 5 methodologies - inverse-variance weighting

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12851721 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature