Chronic pain and risk of gastrointestinal diseases in middle-aged and elderly Chinese adults: The roles of depression and sleep.

ABSTRACT: Chronic pain and gastrointestinal (GI) diseases are prevalent among aging populations. However, their relationship and the potential psychological and behavioral mechanisms remain underexplored. We analyzed data from the 2011 to 2020 China Health and Retirement Longitudinal Study, a nationally representative cohort of adults aged 45 years and older. The cross-sectional analysis (n = 8122) assessed the association between chronic pain and GI diseases, while the longitudinal analysis (n = 4982) examined whether chronic pain predicted incident GI diseases over a 9-year follow-up. Multivariate logistic regression models estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and interaction analyses were conducted to identify potential effect modifiers. Causal mediati

SUBMITTER: Li Q 

PROVIDER: S-EPMC12851733 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature