Osteochondrosis and osteomalacia are distinguished by inflammatory factors and metabolites.

ABSTRACT: Both osteochondrosis and osteomalacia are metabolic disorders that are impacted by a combination of genetic and environmental factors. The objective of this research is to explore the potential causal connection between plasma metabolomics and the development of osteochondrosis and osteomalacia, with a focus on inflammatory factors. Summary statistics were collected for 91 inflammatory cytokine traits, 1400 plasma metabolite traits, and osteochondrosis and osteomalacia traits from publicly accessible genome-wide association studies. Causality was evaluated through two-sample Mendelian randomization analyses, which included methods such as inverse variance weighting, Mendelian randomization-Egger, weighted median, weighted mode, and simple mode analyses. Extensive sensitivity analyses were

SUBMITTER: Chen J 

PROVIDER: S-EPMC12851748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature