The association between omega-3 and omega-6 polyunsaturated fatty acids and 3 cardiac inflammatory diseases: A Mendelian randomization study.

ABSTRACT: The Mediterranean diet exerts beneficial effects on cardiovascular health, though many of its underlying mechanisms remain undefined. While omega-3/6 polyunsaturated fatty acids (PUFAs) present in this dietary pattern may influence cardiac inflammatory conditions, their specific roles in heart diseases require further investigation. Independent single nucleotide polymorphisms associated with omega-3/6 PUFAs and 3 cardiac inflammatory diseases were identified through the IEU Open Genome-Wide Association Study database. Mendelian randomization (MR) analysis was employed to assess potential causal relationships between PUFAs and endocarditis, myocarditis, and pericarditis. The primary analytical approach utilized inverse variance weighting (IVW), complemented by weighted median and MR-Egger m

SUBMITTER: Song Z 

PROVIDER: S-EPMC12851787 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature