Extending the Age Range in Mammography Screening: A Benefit-Risk Assessment from a Radiation Protection Perspective.

ABSTRACT: Mammography screening programs (MSP) are established for women age 50 to 69 years in Germany and Europe. Some of the studies that build the evidence base for these programs also included women who were younger or older than this target population. The aim of our study was to assess whether screening also provides more benefit than harm to women outside the originally defined age range of the German MSP.A systematic review and meta-analysis of randomized controlled trials (RCT) was performed to assess overall and breast cancer mortality in women older than 70 years and women under 50 years. Radiation-associated age-specific lifetime attributable risks (LAR) were estimated based on a modified risk model of the BEIR Committee using current cancer and lifetime data for a female German populati

SUBMITTER: Hunger T 

PROVIDER: S-EPMC12851822 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature