PIM kinase inhibition counters resistance to radiotherapy and chemotherapy in human prostate cancer.

ABSTRACT:

Purpose

PIM kinases are associated with treatment resistance and poor prognosis in prostate cancer through roles in DNA damage response, cellular metabolism, proliferation, and survival. We hypothesized PIM inhibition addresses treatment resistance to radiotherapy and docetaxel in prostate cancer.

Methods

PIM inhibition in prostate cancer cell lines was examined by phosphorylated H2AX and colony formations assays. In normal and castrated mice with prostate tumor xenografts, tumor growth was monitored with daily oral PIM inhibition +/- fractionated radiotherapy (RT) or docetaxel. Radiotherapy was given 30 Gy in 15 treatments, mimicking clinical conventional daily treatment over 3 weeks in a translational murine model system.

Results

PIM inhibition decreased radiotherap

SUBMITTER: Rajkumar-Calkins A 

PROVIDER: S-EPMC12851849 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature