Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells.
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ABSTRACT: Trichloroethylene (TCE) is a volatile organic compound used as an industrial solvent until the recent EPA phaseout. Despite regulatory restrictions, legacy TCE pollution persists in soil and groundwater and poses a risk to human health. This chemical exerts its toxic effects through its metabolites including the glutathione conjugation metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC). Although a known nephrotoxicant, limited research has explored its effects on placental development - despite a reported epidemiological association between maternal exposure and elevated risk of restricted fetal growth. The placenta plays a critical role in the first trimester, functioning under hypoxic conditions to support fetal growth. Extravillous trophoblasts (EVTs), essential for placental developmen
SUBMITTER: Stein FH
PROVIDER: S-EPMC12851871 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
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