The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study.

ABSTRACT:

Background

During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while resuscitation using plasma may preserve glycocalyx health. We hypothesised that resuscitation with plasma would preserve glycocalyx integrity by reducing inflammation, glycocalyx shedding, and dyscoagulation in a controlled model of systemic inflammation in human volunteers.

Methods

Twelve healthy male volunteers were injected with 2 ng kg^-1 lipopolysaccharide (LPS) to induce systemic inflammation. Thirty minutes after LPS administration, participants were randomised to receive 10 ml kg^-1 of either balanced salt solut

SUBMITTER: van den Brink DP 

PROVIDER: S-EPMC12851875 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature