Exclusions affect representativeness of Alzheimer's disease trial participants.

ABSTRACT:

Background

This study assessed how medical exclusion criteria of a prevention Alzheimer's disease trial impact potential eligibility and sample characteristics.

Methods

Medical exclusion criteria from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial were applied to N = 3695 participants from the population-based Health Retirement Study (HRS) with linked Medicare data. We determined the proportion of hypothetical eligibility. Multivariate Poisson regression was used to estimate associations between sociodemographic characteristics and eligibility.

Results

Of the participants, 74.2% (N = 2742) were deemed ineligible. Accounting for all sociodemographic characteristics, older age, female gender, fewer years of education, lower net w

SUBMITTER: Ashford MT 

PROVIDER: S-EPMC12851896 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature