Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single-Cell RNA Sequencing and Molecular Docking.

ABSTRACT: Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti-inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating multiple databases. The protein-protein interaction network was constructed by the STRING platform. Bulk RNA seq data of GSE16134 were included and GO enrichment, GSEA and CIBERSORT algorithm were employed to investigate the immune microenvironment in periodontitis. Single-cell RNA seq data of GSE152042 and GSE171213 were integrated by harmony; the cell-cell communication network was analysed by CellChat, and the differentiation trajectory was constr

SUBMITTER: Chen BJ 

PROVIDER: S-EPMC12851902 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature