Whole-genome landscapes of 1,364 breast cancers.

ABSTRACT: Breast cancer remains a major global health challenge¹. Here, to comprehensively characterize its genomic landscape and the clinical significance of genomic characteristics, we analysed whole-genome sequences from 1,364 clinically annotated breast cancers, with transcriptome data available for most cases. Our study expands the repertoire of oncogenic alterations and identifies novel driver genes, recurrent gene fusions, structural variants and copy number alterations. Timing analyses on copy number alterations suggest that genomic instability emerges decades before tumour diagnosis, and offer insights into early initiation of tumorigenesis. Pattern-driven genomic features, including mutational signatures², homologous recombination deficiency³, tumour mutati

SUBMITTER: Kim R 

PROVIDER: S-EPMC12851938 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature