The efficacy and safety of spesolimab in patients with generalized pustular psoriasis flares: a systematic review and meta-analysis.

ABSTRACT:

Background

Generalized pustular psoriasis (GPP) is a rare, auto-inflammatory skin disease characterized by unpredictable flares, often requiring hospitalization, and current therapies lack robust evidence.

Objectives

To systematically evaluate the efficacy and safety of spesolimab for acute GPP flares.

Methods

We searched Medline, Google Scholar and the Cochrane Central Register of Controlled Trials from inception to December 2024 and consulted ClinicalTrials.gov and the ISRCTN registry for ongoing studies. Randomized controlled trials enrolling adults experiencing GPP flares and comparing spesolimab with placebo or standard care were eligible. Non-randomized studies, studies without placebo comparators, or without full-text availability were excluded. Two reviewers i

SUBMITTER: Alzahrani D 

PROVIDER: S-EPMC12851960 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature