Immune-derived cardiac autonomic signatures: predicting autonomic responses to exercise from B-cell phenotypes.

ABSTRACT:

Objective

Aging affects both immune and autonomic regulation, yet their interaction remains poorly characterized. This study investigated how aging B-cell subpopulations, defined by CD21/CD11c expression, are associated with autonomic nervous system (ANS) dynamics, as measured by heart rate variability (HRV) during exercise in older adults.

Materials and methods

In this cross-sectional study, 81 community-dwelling older adults (mean age 70.7 ± 5.8 years) underwent immune flow cytometry profiling of total B cells and four CD21/CD11c phenotypes. Continuous R-R interval (RRi) data were recorded at rest, during a standardized Two-Minute Step Test (TMST), and over a 5-min recovery period. A coupled-logistic RRi-vs-time model capturing each participant's cardiac autonomic signatur

SUBMITTER: Castillo-Aguilar M 

PROVIDER: S-EPMC12851968 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature