Adiponectin receptor T-cadherin emerges as a novel regulator of adipose stem cell quiescence and adipogenesis.

ABSTRACT: The question of heterogeneity among adipose tissue cells and mesenchymal stem/stromal cells mesenchymal stem cells derived from white adipose tissue has long been a subject of interest. In our study, we conducted a comprehensive single-cell RNA-seq analysis on MSCs isolated from human subcutaneous adipose tissue and maintained under control conditions or upon adipogenic induction. Our findings unveiled a distinct subpopulation of T-cadherin expressing cells, which co-expressed Dipeptidyl peptidase-4 (DPP4⁺), a marker of multipotent progenitors in the adipose tissue. Moreover, T-cadherin co-expressed with DPP4⁺ in early progenitors both, in vivo and in vitro. While adipogenic induction resulted in overall T-cadherin decline, in both the control and differ

SUBMITTER: Sysoeva VY 

PROVIDER: S-EPMC12851984 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature