Brexpiprazole inhibits EMT and migration of colorectal cancer cells by downregulating the SREBP1/SNAI1 signaling pathway.

ABSTRACT:

Objective

To investigate the role and mechanism of the SREBP1/SNAI1 signalling pathway in the effect of brexpiprazole on the EMT and metastasis of CRC.

Methods

The effects of different concentrations of brexpiprazole on cell migration, cell invasion and protein expression in vitro were examined by cell scratch assays, Transwell assays, Western blotting, ELISA, immunofluorescence, and transmission electron microscopy. A dual-luciferase reporter gene assay was used to assess the interactions between SREBP1 and SNAI1. A model of CRC metastasis in nude mice was established, and Western blotting, HE staining, and PET/CT were utilised to explore the effects of brexpiprazole on CRC lung metastasis.

Results

Brexpiprazole significantly inhibited the migration and invasi

SUBMITTER: Liu X 

PROVIDER: S-EPMC12852020 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature