Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?

ABSTRACT:

Background

Diabetic kidney disease (DKD) is the primary cause of kidney failure in type 1 diabetes (T1D). Early identification of subclinical DKD is based on albuminuria and glomerular filtration rate (GFR). However, no GFR equations have been validated in youth with T1D. This study evaluates the performance of GFR equations in youth with T1D.

Methods

We compared a direct measure of GFR (mGFR) via plasma clearance of exogenous inulin, with estimated GFR (eGFR). eGFR was calculated with the following equations: Full-Age Spectrum (FAS-height and FAS-age); revised Lund-Malmö (LM-Rev); European Kidney Function Consortium (EKFC); Chronic Kidney Disease Epidemiology Collaboration, 2009 (CKD-EPI 2009); CKD-EPI 2021 (revised CKD-EPI 2009 without race adjustment); CKD-EPI40 (revised

SUBMITTER: Kumar RS 

PROVIDER: S-EPMC12852128 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature