Prognosis and predictive factors in pediatric IgA nephropathy.

ABSTRACT:

Background

IgA nephropathy (IgAN) is a common glomerular disease in children that may progress to chronic kidney disease (CKD) and kidney failure. Identifying reliable prognostic markers is important for guiding clinical management. This study investigated independent predictors of poor prognosis in pediatric IgAN and their impact on eGFR slope, as well as the dynamic patterns of complete kidney remission and relapse, predictive factors associated with remission, and the influence of remission on poor prognosis.

Methods

A retrospective cohort study of 224 children (aged 3-18 years) with biopsy-proven IgAN and ≥ 3 years of follow-up was enrolled. Poor prognosis was defined as persistent eGFR < 90 mL/min/1.73 m² for ≥ 3 months. Multivariate logistic regression, rece

SUBMITTER: Liang W 

PROVIDER: S-EPMC12852140 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature