Evaluating Transferability of ComBat Harmonization of Diffusion Tensor Magnetic Resonance Imaging Data.

ABSTRACT:

Purpose

Traditional use of the ComBat data harmonization method (a popular means of harmonizing multisite MRI data) is limited by the requirement that the harmonization must be recomputed with any addition of new subjects to the data pool. The goal of this study was to assess whether a transferable ComBat (T-ComBat) algorithm could be applied such that harmonization parameters computed using ComBat on a fixed set of diffusion tensor (DT) MRI training subject data could be reapplied to harmonize new, previously unseen subject data without alteration of the harmonized training data. Emphasis was given to evaluating the necessary size of such a training data pool.

Methods

Fractional anisotropy (FA) and mean diffusivity (MD) maps for 314 adolescents were harmonized across two MR

SUBMITTER: Fitzgerald B 

PROVIDER: S-EPMC12852171 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature