Breast cancer risk level and prediction of tumor aggressiveness in the Athena Breast Health Network.

ABSTRACT:

Purpose

Determine the association between the Breast Cancer Surveillance Consortium v2 model (BCSC) risk score and advanced and non-advanced invasive breast cancer (IBC).

Methods

We estimated BCSC 5-year invasive breast cancer risk for 11,915 participants in a prospective screening cohort with median follow-up of 6.9 years prior to breast cancer diagnosis. Individuals in the top 25% by age of BCSC risk standard were considered high-risk, those in the bottom 75% low-risk. We obtained cancer outcomes, including American Joint Committee on Cancer (AJCC) prognostic pathologic stage, from the San Francisco Mammography Registry and an institutional cancer registry. We examined the associations of BCSC risk scores with advanced (≥ AJCC prognostic stage II) and non-advanced (AJCC pr

SUBMITTER: Leggat-Barr K 

PROVIDER: S-EPMC12852213 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature