Endothelial USP8 is essential for angiogenesis.

ABSTRACT: Angiogenesis, the formation of new blood vessels from existing ones, is crucial for both development and disease. Its dysregulation is associated with diseases such as cancer, obesity, and blindness. Vascular endothelial growth factor A (VEGFA) signaling through VEGF receptor 2 (VEGFR2) is the central regulator of angiogenesis. Consequently, there is significant interest in identifying modulators of this pathway to develop targeted therapeutic interventions. Ubiquitination tags proteins for degradation, whereas deubiquitinases counteract this process by removing the attached ubiquitin molecules. Previous studies have shown that the deubiquitinase Ubiquitin-Specific Protease 8 (USP8) regulates VEGFR2 trafficking and activation in vitro, suggesting that USP8 may regulate endothelial cell fun

SUBMITTER: Pau-Navalon A 

PROVIDER: S-EPMC12852293 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature