Structural and functional coupling alterations in autism spectrum disorder with and without comorbid attention deficit hyperactivity disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are highly comorbid. The neural basis of this comorbidity remains unclear. We compared brain structural-functional coupling (SC-FC coupling) across ASD subgroups and typically developing (TD) controls to parse the neurobiological heterogeneity of ASD.

Methods

We analyzed T1-weighted and resting-state fMRI data from 331 participants from ABIDE II (130 ASD [39 ASD+ADHD, 91 ASD-only] and 201 TD). For each participant, we extracted multivariate structural features from T1-weighted images to construct an individual structural covariance network. SC-FC coupling for each brain region was quantified by correlating its observed functional connectivity profile with the profile predicted from

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12852334 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature