Longitudinal evolution and risk profiles of comorbidity among people with HIV in China: a retrospective cohort study.

ABSTRACT:

Objective

With increased longevity among people with HIV (PWH), multimorbidity has become a major challenge, but its long-term evolution remains poorly described. We aimed to characterize the longitudinal evolution of comorbidity and identify risk profiles for metabolic and mixed infectious-non-infectious multimorbidity among PWH initiating antiretroviral therapy in China.

Methods

We conducted a retrospective cohort study of 5,950 PWH initiating antiretroviral therapy (ART) in Shenzhen, China (2009-2016), with follow-up through 2024. Twenty-six predefined comorbid conditions were classified as curable or incurable. Multimorbidity was defined as ≥2 conditions and grouped into six mutually exclusive comorbidity states. Evolution over 8 years was described using Sankey diagrams

SUBMITTER: Liu C 

PROVIDER: S-EPMC12852350 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature