Different transcriptional regulatory activities of Mycobacterium bovis and Mycobacterium tuberculosis PhoPR systems.

ABSTRACT: Tuberculosis (TB) is an infectious disease that affects humans and animals. The pathogens that cause TB belong to the Mycobacterium tuberculosis complex (MTBC), with M. tuberculosis and Mycobacterium bovis as the main representatives of human- and animal-adapted strains, respectively. One key genetic regulator of the MTBC members is the PhoPR system, which controls many processes, including the stress response, lipid metabolism and pathogenesis, among others. Previous studies identified a key G71I substitution in the M. bovis PhoR orthologue relative to M. tuberculosis PhoR and suggested that PhoPR might be non-functional in animal-adapted strains, but recent work has highlighted the functionality of PhoPR in M. bovis despite the G71I substitution.

SUBMITTER: Urtasun-Elizari JM 

PROVIDER: S-EPMC12852370 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature