Dataset Information

Identifying common genetic etiologies between iridocyclitis and related immune-mediated diseases.

ABSTRACT:

Background

Patients with iridocyclitis are at heightened risk for immune-mediated diseases. The genetic underpinnings of iridocyclitis are intricate, necessitating an integrated approach to unravel the genetic connections between iridocyclitis and these diseases.

Methods

GWAS data were integrated from three databases using METAL. Independent risk loci were analyzed through conditional and joint genome-wide multi-trait analysis, multi-marker genomic annotation, and functional mapping of significant loci. This approach combined quantitative trait loci data and various methodologies to identify genes and proteins associated with risk. Target gene verification was conducted through cell experiments and flow cytometry.