Identify the therapeutic role and potential mechanism of α-cyperone in diminished ovarian reserve based on network pharmacology, molecular docking, Lip-MS and experimental validation.

ABSTRACT:

Background

The presence of diminished ovarian reserve (DOR) poses a significant threat to female fertility, with no current effective treatment available. Inflammation plays pivotal roles in the pathogenesis of DOR. α-Cyperone (AC) exhibits notable anti-inflammatory and anti-oxidative properties; however, its potential for improving DOR remains unexplored.

Methods

The PubChem, PharmMapper, and SwissTargetForecast databases were queried to retrieve biochemical information and drug targets for AC. The identification of disease targets for DOR involved referring to the OMIM and Genecards databases. AC's therapeutic targets against DOR were determined by examining the overlap between drug targets and disease targets. To analyze GO function enrichment, KEGG pathway, and disease a

SUBMITTER: Guo J 

PROVIDER: S-EPMC12852401 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature