Antimycobacterial activity of intertidal sediment-derived bacteria from False Bay, South Africa.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global health burden due to the pathogen's ability to develop resistance to current treatment options. Consequently, drug discovery studies are essential for identifying new antimycobacterial agents with novel mechanisms of action. This study investigated the antimycobacterial activity of crude extracts derived from mixed culturable bacteria isolated from intertidal marine sediments. The bacterial diversity of the bioactive mixed cultures was characterized using 16S rRNA gene-based metagenomic analysis. Their pathogen-targeted effects were evaluated against Mycobacterium smegmatis mc²155 and M. tuberculosis H37Rv, and THP-1-derived macrophages infected with M. smegmatis mc²1

SUBMITTER: Thagulisi F 

PROVIDER: S-EPMC12852442 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature