Diagnostic potential of salivary biomarkers for primary biliary cholangitis: a systematic review.

ABSTRACT:

Background

Recent studies have explored saliva as a non-invasive diagnostic fluid across various systemic and autoimmune conditions. However, its potential role in diagnosing primary biliary cholangitis (PBC) remains unclear.

Aim

This systematic review examines whether salivary biomarkers can assist in the diagnosis of PBC.

Materials and methods

Indexed databases (PubMed and Scopus) and bibliographies of relevant articles were searched between November 2024 and December 2024. Original cross-sectional studies investigating salivary biomarkers specifically for PBC diagnosis were included. Quality appraisal was conducted using the Joanna Briggs Institute (JBI) critical appraisal checklist.

Results

Three studies involving 204 participants met the inclusion criteria

SUBMITTER: Saeed M 

PROVIDER: S-EPMC12852463 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature