Prognostic impact of lymphocyte to monocyte ratio in patients with myelodysplastic neoplasms/syndromes.

ABSTRACT:

Purpose

Myelodysplastic syndromes/neoplasms (MDS) represent a heterogeneous group of clonal hematopoietic disorders with variable prognosis. While several risk models exist, the prognostic role of immune-related biomarkers remains unclear. This study aimed to determine whether the lymphocyte-to-monocyte (L/M) ratio at diagnosis serves as an independent prognostic factor in MDS and to explore its biological correlates.

Methods

A retrospective analysis of 554 patients with primary MDS diagnosed at the National Taiwan University Hospital was conducted. Patients were stratified by an L/M ratio cutoff of 1.5, determined by maximally selected rank statistics. Clinical, cytogenetic, and mutational profiles were assessed. Survival outcomes were analyzed using Kaplan-Meier methods an

SUBMITTER: Lee WH 

PROVIDER: S-EPMC12852561 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature