Natural history of simple and complex cysts in autosomal dominant polycystic kidney disease on MRI.

ABSTRACT:

Background

Kidney volume, reflecting cumulative effects of many cysts, is an important prognostic biomarker for autosomal dominant polycystic kidney disease (ADPKD) but fails in many patients. Tracking individual cysts may more directly assess disease progression.

Methods

Individual cysts (n = 299) from 37 subjects were evaluated retrospectively over ≥ 8 years by serial MRI (mean follow-up = 11 years). Cysts were labeled on every available MRI scan, totaling 1654 contours (median timepoints per cyst = 5). Effects of cyst location, morphology, and growth pattern on kidney function decline were evaluated by univariate and multivariate analyses.

Results

Simple, T2-bright cysts follow logistic growth (median cyst growth rate = 11%/year). A subset (94/222, 42%) transitions

SUBMITTER: Hu Z 

PROVIDER: S-EPMC12852659 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature