Gestational physical exercise prevents early-life behavioral impairments in the offspring of a rat model of attention deficit hyperactivity disorder.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is a developmental condition characterized by symptoms of inattention, hyperactivity, and impulsivity. Spontaneously hypertensive rats (SHRs) comprise an ADHD rodent model that exhibits behavioral impairments recapitulating phenotypes observed in humans. SHRs further develop dopaminergic hypofunction in frontostriatal circuits and an imbalance in dopamine and norepinephrine systems. Maternal physical exercise, such as swimming, during pregnancy was shown to enhance offspring angiogenesis and neurogenesis, and to improve memory in rodents. Herein we determined the impact of gestational swimming on behavioral and dopaminergic parameters in childhood (1-2 week-old rats) and adolescence (4-5 week-old rats) of SHR and Wistar Kyoto rats (WKYs), use

SUBMITTER: Tosta A 

PROVIDER: S-EPMC12852695 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature