Mitoxantrone alters CD24/Siglec-10 expression in malignant brain tumor models.

ABSTRACT: Medulloblastoma and glioblastoma are the most common malignant primary brain tumors in children and adults, respectively. Tumor-associated macrophages and microglia are key non-cancerous cell types in these tumors. These cells interact with CD24, a so called "don't eat me signal" expressed on tumor cells, through Siglec-10, a receptor that contributes to immune evasion by promoting an immunosuppressive environment. The CD24/Siglec-10 interaction in context of malignant brain tumors has been scarcely studied.In silico analyses reveal that CD24 gene expression correlates with specific gene signatures associated with prognosis in both medulloblastoma and glioblastoma. In both human- and mouse brain tumors, Siglec-10⁺ cells co-express the microglia-associated molecule TREM2. Treatme

SUBMITTER: Kopecky J 

PROVIDER: S-EPMC12852714 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature