Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis.

ABSTRACT:

Background

Translating trial findings to real-world cure rates for resectable oesophageal and gastroesophageal junction (GEJ) adenocarcinoma is critical. Standard endpoints like disease-free survival (DFS) may not distinguish durable cures from delayed recurrences.

Methods

This analysis of the AGAMENON-SEOM registry (NCT04958720) compared perioperative chemotherapy versus neoadjuvant chemoradiotherapy (nCRT). We estimated cure rates and analysed DFS and overall survival (OS) using mixture cure models and Cox proportional hazards models.

Results

In 500 patients, perioperative FLOT improved DFS (HR 0.60; p = 0.01) and OS (adjusted HR 0.63; p = 0.015) compared to CROSS-based nCRT. Notably, cure models confirmed a higher cure fraction for FLOT in high-risk subgroups (e.g.

SUBMITTER: Mateos L 

PROVIDER: S-EPMC12852715 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature