Seasonal impact of PM_2.5 on pro-oncogenic drivers among participants of a thermal power plant in India.

ABSTRACT: Molecular epidemiology targeting the impact of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM_2.5) on pro-oncogenic signaling has been sparsely reported from the Indian industrial belt. This study investigated the effect of seasonal variation in PM_2.5 on pro-oncogenic drivers in the pulmonary and systemic cellular environments of a thermal power plant participants in West Bengal, India during 2021-2022. PM_2.5 levels were significantly higher during spring than monsoon, coinciding with reduced hemoglobin and lung function indices. Linear Mixed-Effects Regression (LMER) confirmed that elevated PM_2.5 exposure was significantly associated with increased inflammatory response, enhanced matrix metalloproteinase-9 (MMP-9) activity, and upregulat

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC12852786 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature