Exploring translational relevance of baseline and longitudinal metabolic profiling in the blood of ovarian cancer patients.

ABSTRACT: We conducted blood-based metabolomic profiling in ovarian cancer and determined its clinical relevance. NMR spectroscopy was performed on a total of n = 760 longitudinal plasma samples from n = 292 ovarian cancer patients, probing for n = 39 metabolites. At primary diagnosis, we revealed two distinguishable signatures, representing blood-based surrogates for a continuum of two metabolic states in ovarian cancer. These signatures shaped two subgroups of patients with differential surgical outcome and relapse risk (HR = 1.605, 95%CI:1.11-2.32, p = 0.009). Deconvolution of the metabolomic signatures identified acetoacetate, 3-hydroxybutyrate and alanine among the most relevant signature-determining metabolites. The acetoacetate^low/3-hydroxybutyrate^low/alanine^high

SUBMITTER: Funk AM 

PROVIDER: S-EPMC12852794 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature