Expression of antibody-drug conjugate targets in post-mortem samples of breast cancer metastases and normal tissue.

ABSTRACT: While many Antibody Drug Conjugates (ADCs) are investigated in solid tumors, their target expression and heterogeneity is poorly documented in metastatic breast cancer. Here, we perform RNA sequencing to investigate expression of 72 ADC targets in 909 samples from 30 female patients from our post-mortem tissue donation program UPTIDER (NCT04531696). We report that the highest median expression in metastases is seen for FN1, MUC1, LAMP1, HER3 and SLC39A6. TROP2 and HER2 have the 9^th and 27^th highest expression. We observe reduced expression in metastases as compared to primary untreated tumors for 15 targets but observe only limited differences in expression between metastases of different subtypes. We show that TROP2, VTCN1, NECTIN4, HER2 and HER3 are interesting targ

SUBMITTER: Borremans K 

PROVIDER: S-EPMC12852894 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature