Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.

ABSTRACT: Selective activation of small versus large diameter nerve fibers represents a broad challenge in the electrical modulation of neural activity for clinical applications. For example, off-target activation of motor nerve fibers was implicated in several failed vagus nerve stimulation (VNS) clinical trials by effectively limiting maximum applicable current amplitudes, thereby preventing robust activation of smaller diameter fibers responsible for therapeutic effects. Kilohertz high-frequency (HF) block is one of several strategies proposed to overcome this gap, but has yet to be thoroughly investigated in large, multifascicular, mixed nerves comparable in scale to humans. Here, we evaluated effects of HF block on the neural, muscular, and cardiac responses evoked by traditional low-frequency

SUBMITTER: Cheng KP 

PROVIDER: S-EPMC12852918 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature