Recombinant Human Amelogenin Protein Enhances Tendon-To-Bone Healing in a Rat Rotator Cuff Tear Model.

ABSTRACT: Rotator cuff tears (RCTs) often require surgical intervention; however, surgical outcome is frequently insufficient due to poor healing of the tendon-bone enthesis, leading to high retear rates. Previously, the recombinant human amelogenin protein (rHAM⁺) regenerated injured or diseased musculoskeletal tissues including ligaments and osteochondral injuries. We therefore hypothesized that rHAM⁺ can also induce regeneration of the biomechanical and structural properties of the enthesis. The right shoulder infraspinatus tendon of 75 rats was fully-transected, and treated either with 0.5 mg/mL rHAM⁺ dissolved in propylene glycol alginate (PGA) carrier (n = 30), or with PGA carrier alone (n = 30). Fifteen unoperated rats were additionally evaluated. Four- and ei

SUBMITTER: Markowitz SI 

PROVIDER: S-EPMC12853009 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature