Multi-platform integration of brain and CSF proteomes reveals biomarker panels for Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the leading cause of dementia and represents a progressive, irreversible neurodegenerative disorder. Given the complexity and heterogeneity of AD, which involves numerous interrelated molecular pathways, large-scale proteomics datasets are essential for robust biomarker discovery. Comprehensive proteomic profiling enables the unbiased identification of novel biomarkers across diverse biological processes, thereby increasing the likelihood of finding sensitive and specific candidates for early diagnosis and therapeutic targeting. In this study, we analyzed 28 large-scale proteomics datasets obtained from the AD Knowledge Portal and published studies. The data comprise tandem mass tag, label-free quantification, and proximity extension assay measurements from brai

SUBMITTER: Tsai WY 

PROVIDER: S-EPMC12853123 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature