Deciphering the Role of Sirtuin-1 Gene Polymorphism in Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

ABSTRACT: Sirtuin-1-gene (SIRT1) plays a key role in regulating metabolic and inflammatory processes. This review is aimed at evaluating the association between SIRT1-polymorphisms and diabetic nephropathy susceptibility. Observational-cohort and case-control studies were included. Data extraction followed PRISMA 2020 guidelines, and study quality was assessed using the Newcastle-Ottawa Scale. Meta-analysis was done using a random-effects model, with heterogeneity and publication bias assessed using I ² statistics and funnel plots. Subgroup analyses were done by ethnicity and genotyping methods. Meta-analysis showed SIRT1-polymorphisms rs7895833 (OR: 2.71, 95% CI: 2.67-2.76) and rs2273773 (OR: 1.51, 95% CI: 1.16-1.97) to be significantly associated with increas

SUBMITTER: Moin H 

PROVIDER: S-EPMC12853138 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature