Ciprofol versus propofol for sedation in colonoscopy: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Ciprofol has emerged as a potential alternative sedative with improved safety and efficacy. However, comparative data for colonoscopy sedation remain limited.

Methods

A systematic search in PubMed, Embase, Cochrane Library, and Web of Science identified RCTs published through August 2025. Studies included patients undergoing colonoscopy using ciprofol or propofol, reporting relevant efficacy or safety outcomes. Risk Ratios (RRs) and Mean Differences (MDs) were calculated using the Mantel-Haenszel random-effects model and 95% Confidence Intervals. The heterogeneity was assessed with I² statistics and Cochrane Q test. Primary outcomes were procedure success rate and patient satisfaction (assessed on a 1-to-10 scale). Secondary outcomes included sedation onset time(s

SUBMITTER: Dominici S 

PROVIDER: S-EPMC12853187 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature