A note on rank-preserving structural failure time models to account for crossover.

ABSTRACT:

Background

In randomized trials where some standard-treatment arm patients cross to the experimental treatment, it is frequently of interest to estimate the between-arm survival difference as if no patients on the standard-treatment arm had crossed over to the experimental treatment. Rank-preserving structural failure time models, an extension of semiparametric accelerated-failure-time models, are a popular method for accomplishing this because they do not require modeling which patients will crossover.

Methods

In trying to apply the rank-preserving structural failure time model in practice, we noted some unusual behavior of the estimated acceleration parameter (differential treatment effect). Simple examples and limited simulations are provided to examine and understand thi

SUBMITTER: Torres-Saavedra PA 

PROVIDER: S-EPMC12853195 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature