Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study.

ABSTRACT: Neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), have heterogeneous behavioral phenotypes and substantial symptom overlap. Identifying transdiagnostic subgroups may help clarify this heterogeneity. This study aimed to identify behavior-based subgroups of children with NDD and explore links between gastrointestinal (GI) symptoms and behavioral symptoms. Using data from the Province of Ontario Neurodevelopmental Disorders (POND) network, we applied a heterogeneous mixture model (HMM) to behavioral data from 1716 participants, including typically developing (TD, n = 210), ASD (n = 747), and ADHD (n = 759) and identified six distinct clusters. Five of the clusters included individuals with TD, ADHD, and ASD diagno

SUBMITTER: Cleary S 

PROVIDER: S-EPMC12853231 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature