Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study.

ABSTRACT:

Background

Only half of patients appear adherent to antihypertensive treatment. If so, the effectiveness in prevention against adverse cardiovascular outcomes may depend more on a drugs' side effects than its blood pressure effects. We hypothesized that initiating treatment with a particular antihypertensive drug class will determine later persistence.

Methods

We applied a new-user trial emulation approach to multiple mandatory health-care registers in Sweden. All individuals starting antihypertensive treatment with an angiotensin receptor blocker (ARB), angiotensin converting enzyme inhibitor (ACEi), calcium channel blocker (CCB), thiazide/thiazide-like diuretic (TD), or single-pill combination of two drugs (SPC) in 2011-2018 were assessed for inclusion. Patients with prior

SUBMITTER: Laurell K 

PROVIDER: S-EPMC12853357 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature