Transcription factor BRCA1 is associated with BMPR1B transcriptional activity in sheep ovarian granulosa cells.

ABSTRACT: BMPR1B is a well-characterized major gene associated with prolificacy in sheep. The FecB mutation in this gene promotes accelerated follicular development and increases ovulation rate, thereby enhancing litter size. Although BMPR1B plays a crucial role in reproduction, the regulatory mechanisms of its expression in sheep tissues are not yet fully understood. This study identified the promoter region of the BMPR1B gene and provided evidence that its transcriptional activity is associated with regulation by the transcription factor BRCA1. Luciferase reporter assays showed that the P1 fragment containing the BMPR1B promoter region had gene expression-driving activity; importantly, two BRCA1 binding sites (BBS) were identified within this promoter region. Subsequent experimental results sugges

SUBMITTER: Abdurahman A 

PROVIDER: S-EPMC12853376 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature