Comparing Different As-Treated Approaches: A Methodological Study Using Real-World Data on Psoriasis Treatments.

ABSTRACT:

Background

Accurate pharmaco-epidemiological assessment of the safety of biological treatments is essential but methodologically challenging.

Aims

This study evaluated how different assumptions regarding treatment switching and treatment episode definitions affect outcome estimates in psoriasis patients, focusing on malignancies and serious infections.

Methods

Data from Danish national registers (2009-2022) were analyzed for hospitalized psoriasis patients treated with ustekinumab, non-biologics, tumor necrosis factor-α inhibitors, and other interleukin inhibitors excluding ustekinumab. Various as-treated approaches were assessed and compared to the Intention-to-Treat (ITT) approach. The as-treated approaches included: (1) RC-switch, considering switching only between

SUBMITTER: Kim S 

PROVIDER: S-EPMC12853409 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature