Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury.

ABSTRACT:

Background

While delivery of supplemental oxygen is a life-saving therapy, exposure to high oxygen, called hyperoxia, leads to increased intensive care unit mortality. Hyperoxia induces oxidant-mediated acute lung injury (ALI) and pulmonary cell death, called hyperoxic ALI (HALI). Elucidating molecular mechanisms in HALI could identify therapeutic targets in ALI.

Methods

In the current study, we examined in vivo effects of HALI on Beclin-1 (BCN1), which regulates autophagy, and modulation of BCN1 by epidermal growth factor receptor (EGFR). Effects of HALI on BCN1 and autophagy were examined in mice with genetically decreased EGFR (EGFR^Wa5/+). Wildtype (WT) and EGFR^Wa5/+ mice were exposed to 100% oxygen for 24-72 hours along with normoxia controls (eight

SUBMITTER: Harris ZM 

PROVIDER: S-EPMC12853440 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature