Oncolytic peptide LTX-315 targets PD-L1 to improve antitumor immune response of nanosecond pulse electric field in liver cancer.

ABSTRACT:

Background

Nanosecond pulsed electric field (nsPEF) ablation has demonstrated limited and transient efficacy in suppressing tumor progression. Oncolytic peptide LTX-315 is known to elicit a strong antitumor immune response and durable immune memory. This study aimed to investigate whether LTX-315 could enhance nsPEF-induced antitumor immunity in liver cancer.

Methods

Both cell assays and mouse models were used to evaluate the therapeutic efficacy of nsPEF, LTX-315, and combination therapy. Flow cytometry and immunofluorescence were performed to assess the tumor immune microenvironment. Co-culture models were established to evaluate the functional modulation of immune cells.

Results

nsPEF upregulated the programmed cell death 1 ligand 1 (PD-L1) expression in liver canc

SUBMITTER: Ji K 

PROVIDER: S-EPMC12853467 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature