Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun.

ABSTRACT:

Objective

SLE is a multifaceted chronic inflammatory disorder characterised by a dysregulated immune response that involves various organ systems, with significant implications stemming from the type I interferon (IFN) signalling pathway in its pathogenesis. This study aimed to elucidate the contributory role of the IFN-induced protein 44-like (IFI44L) gene in SLE progression and to investigate its transcriptional regulatory mechanisms.

Methods

We quantified IFI44L expression in peripheral blood mononuclear cells of patients with SLE through quantitative PCR (qPCR), and established an in vitro THP-1 cell model overexpressing IFI44L to assess its impact under IFN-α exposure using Cell Counting Kit-8 assays and flow cytometry. Additionally, we generated

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12853510 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature