Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Unexplained infertility affects about 30% of couples seeking help for infertility, yet the optimal ovulation induction strategy remains largely unclear. Letrozole, clomiphene citrate and gonadotropins are widely used, alone or in combination, with or without intrauterine insemination (IUI), but evidence of comparative effectiveness and safety is inconsistent. Most reviews are restricted to pairwise comparisons or mixed infertility populations. This protocol describes a systematic review and network meta-analysis (NMA) to compare ovulation induction strategies specifically in unexplained infertility.

Methods and analysis

Parallel-group randomised controlled trials (RCTs), including women aged 18-40 years with unexplained infertility, will be eligible. Interventio

SUBMITTER: Mehta P 

PROVIDER: S-EPMC12853524 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature