Evaluation of NTD-O2, a Ghanaian herbal medicine, for onchocerciasis and animal African trypanosomiasis.

ABSTRACT:

Background

Herbal medicine remains central to primary healthcare in Ghana due to its accessibility and perceived safety. NTD-O2 is an aqueous herbal formulation derived from Xylopia aethiopica fruits and Bambusa vulgaris leaves, traditionally used for managing onchocerciasis, a neglected tropical disease (NTD) endemic to the country. This study evaluated the antionchocercal activity of NTD-O2 and assessed isolated compounds from the formulation and its source plants for activity against animal African trypanosomiasis, another prevalent NTD.

Methods

Dichloromethane (DCM) and butanol (BuOH) extracts of NTD-O2 were screened in vitro against Onchocerca ochengi and Trypanosoma brucei brucei. Bioassay-guided fractionation, coupled with spectroscopic and spectrometric techniques, f

SUBMITTER: Anibea BZ 

PROVIDER: S-EPMC12853598 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature